From Wilmington:
| 4: | Stay STRAIGHT to go onto I-40 W. | 127.5 miles | Map | |
| 5: | Take the I-440 / US-1 / US-64 exit- EXIT 293- toward RALEIGH / WAKE FOREST / SANFORD. | 0.5 miles | Map | |
| 6: | Merge onto US-1 S via EXIT 293A toward SANFORD / ASHEBORO. | 23.4 miles | Map | |
| 7: | Take the OLD US-1 / DEEP RIVER RD exit- EXIT 78. | 0.2 miles | Map | |
| 8: | Turn LEFT onto OLD US-1. | 0.3 miles | Map | |
| 9: | Turn RIGHT onto LOWER MONCURE RD. | 0.7 miles | Map | |
| 10: | Turn LEFT onto LOWER RIVER RD. | 2.1 miles | Map | |
| 11: | End at 4080 Lower River Rd Sanford, NC 27330-3165, US | |||
From Florence, South Carolina:
| 3: | Merge onto I-95 N. | 80.1 miles | Map | |
| 4: | Take the NC-87 exit- EXIT 46- toward ELIZABETHTOWN / FAYETTEVILLE. | 0.2 miles | Map | |
| 5: | Take the NC-87 N exit- EXIT 46A- on the LEFT toward FAYETTEVILLE. | 0.4 miles | Map | |
| 6: | Merge onto NC-87 N via EXIT 46B toward FAYETTEVILLE. | 4.0 miles | Map | |
| 7: | Take the I-95-BR / EASTERN BOULEVARD / US-301 exit- EXIT 102. | 0.2 miles | Map | |
| 8: | Turn RIGHT onto I-95 BR N / US-301 N / S EASTERN BLVD / GILLESPIE ST. Continue to follow I-95 BR N / US-301 N. | 1.6 miles | Map | |
| 9: | Turn LEFT onto NC-210 / NC-24 / GROVE ST. Continue to follow NC-24 W. | 20.2 miles | Map | |
| 10: | NC-24 W becomes NC-87. | 18.5 miles | Map | |
| 11: | Turn LEFT to take the US-1-BYP N / US-15 N / US-501 N / NC-87 N ramp toward RALEIGH. | 0.1 miles | Map | |
| 12: | Merge onto US-1 N. | 10.0 miles | Map | |
| 13: | Take the OLD US-1 / DEEP RIVER RD exit- EXIT 78. | 0.2 miles | Map | |
| 14: | Turn RIGHT onto OLD US-1. | 0.1 miles | Map | |
| 15: | Turn RIGHT onto LOWER MONCURE RD. | 0.7 miles | Map | |
| 16: | Turn LEFT onto LOWER RIVER RD. | 2.1 miles | Map | |
| 17: |
End at 4080 Lower River Rd | |||
From Danville, Virginia:
| 1: | Start out going SOUTHWEST on MAIN ST / VA-293 W toward JEFFERSON AVENUE EXT. | 0.8 miles | Map | |
| 2: | Merge onto VA-86 S toward CHAPEL HILL. | 2.3 miles | Map | |
| 3: | Merge onto US-58 W / DANVILLE EXPY / US-29 S toward GREENBORO. | 3.7 miles | Map | |
| 4: | Merge onto US-29 S via the exit on the LEFT toward GREENSBORO. | 40.2 miles | Map | |
| 5: | Take the US-421 / MARTIN L KING JR DR exit on the LEFT toward I-85 N / SANFORD / I-40 E. | 0.3 miles | Map | |
| 6: | Turn LEFT onto MARTIN LUTHER KING JR DR / US-421. Continue to follow US-421 S. | 52.4 miles | Map | |
| 7: | Take the US-1-BYP N / US-501 N / NC-87 N / US-15 N ramp toward RALEIGH. | 0.1 miles | Map | |
| 8: | Merge onto US-1 N. | 10.0 miles | Map | |
| 9: | Take the OLD US-1 / DEEP RIVER RD exit- EXIT 78. | 0.2 miles | Map | |
| 10: | Turn RIGHT onto OLD US-1. | 0.1 miles | Map | |
| 11: | Turn RIGHT onto LOWER MONCURE RD. | 0.7 miles | Map | |
| 12: | Turn LEFT onto LOWER RIVER RD. | 2.1 miles | Map | |
| 13: |
End at 4080 Lower River Rd | |||
From Charlotte, NC:
| 3: | Merge onto I-277 N / W BROOKSHIRE FWY / NC-16 W via the ramp on the LEFT. | 0.8 miles | Map | |
| 4: | Merge onto I-77 N / US-21 N via EXIT 5A toward I-85 / STATESVILLE. | 1.7 miles | Map | |
| 5: | Merge onto I-85 N via EXIT 13A toward GREENSBORO. | 87.5 miles | Map | |
| 6: | Take the US-421 exit- EXIT 126- toward SANFORD. | 0.2 miles | Map | |
| 7: | Merge onto US-421 S via EXIT 126A toward SANFORD. | 49.1 miles | Map | |
| 8: | Take the US-1-BYP N / US-501 N / NC-87 N / US-15 N exit toward RALEIGH. | 0.1 miles | Map | |
| 9: | Merge onto US-1 N. | 10.0 miles | Map | |
| 10: | Take the OLD US-1 / DEEP RIVER RD exit- EXIT 78. | 0.2 miles | Map | |
| 11: | Turn RIGHT onto OLD US-1. | 0.1 miles | Map | |
| 12: | Turn RIGHT onto LOWER MONCURE RD. | 0.7 miles | Map | |
| 13: | Turn LEFT onto LOWER RIVER RD. | 2.1 miles | Map | |
| 14: | End at 4080 Lower River Rd Sanford, NC 27330-3165, US | |||
From Atlanta, Georgia
| 3: | Merge onto I-85 N via the ramp on the LEFT. | 330.4 miles | Map | |
| 4: | Take the US-421 exit- EXIT 126- toward SANFORD. | 0.2 miles | Map | |
| 5: | Merge onto US-421 S via EXIT 126A toward SANFORD. | 49.1 miles | Map | |
| 6: | Take the US-1-BYP N / US-501 N / NC-87 N / US-15 N exit toward RALEIGH. | 0.1 miles | Map | |
| 7: | Merge onto US-1 N. | 10.0 miles | Map | |
| 8: | Take the OLD US-1 / DEEP RIVER RD exit- EXIT 78. | 0.2 miles | Map | |
| 9: | Turn RIGHT onto OLD US-1. | 0.1 miles | Map | |
| 10: | Turn RIGHT onto LOWER MONCURE RD. | 0.7 miles | Map | |
| 11: | Turn LEFT onto LOWER RIVER RD. | 2.1 miles | Map | |
| 12: | End at 4080 Lower River Rd Sanford, NC 27330-3165, US | |||